Publications

1. Sahu I, Zhu He, Buhrlage Sara*, Marto Jarrod A*. Proteomic approaches to study ubiquitinomics. Accepted for publication at BBA – Gene Regulatory Mechanisms. (2023).
2. Sahoo M.P#, Levi T#, Sahu I, Kleifeld O*. Activity-Guided Proteomic Profiling of Proteasomes Uncovers a Variety of Active (and Inactive) Proteasome species. BioRxiv April 2023.
3. Sahu I#*, Bajorek M#, Osmulski P, Krutauz D, Reis N, Gaczynska M, Glickman M.H*. A unique role for the N-terminus of the alpha-2 subunit in aiding substrate translocation into the catalytic core of the proteasome. Biomolecules. (2023), 3(3), 480. [* Corresponding Author, # Equal Contribution].
4. Sahu I*, Sahoo M.P, Kleifeld O*, Glickman M.H*. Isolation of Proteasome-Trapped Peptides (PTPs) for degradome analysis. Methods in Molecular Biology. (2023), 2602: 229–241. [* Corresponding Author].
5. Sahu I, Mali S.M, Sulkshane P, Morag R, […], Day S, Cong Y, Kleifeld O, Brik A*, Glickman M.H*. The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications (2021), 12, 6173. See publication. Featured article on Editors’ Highlights webpage https://www.nature.com/collections/hhfigaahch
6. Sahu I* and Glickman M.H*. “Proteasome in action” – Substrate degradation by the 26S proteasome. Biochemical Society Transactions (2021), 49 (2): 629–644. [* Corresponding Author].
7. Sahu I* and Glickman, M.H*. Structural insights into substrate recognition and processing by the 20S Proteasome. Biomolecules (2021), 11(2), 148. [* Corresponding Author].
8. Tiwari R, Ganguli N, Alam H, Sahu I, Vadivel C, […], Manjumdar, Vaidya M.M*. Generation of tissue specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo. Cell Biol Int. (2021) Apr 13.
9. Sahu I, Nanaware Padma, Mane M, Mulla W.S, Roy S, and Venkatraman P*. Role of a 19S Proteasome Subunit- PSMD10/Gankyrin in Neurogenesis of human Neural Progenitor Cells. International Journal of Stem cells. (2019) Vol. 12, (3), 463-473.
10. Ding Z, Xu C, Sahu I, Wang Y, […], Glickman M.H*, Cong Y*. Structural snapshots of 26S proteasome reveal tetraubiquitin-induced conformations. Molecular Cell. (2019) Vol. 73 (6), 1150-1161.
11. Tiwari R, Sahu I, Soni B, […], Gowda H, and Vaidya M.M*. Depletion of Keratin 8/18 modulate oncogenic potential of A431 cells by governing multiple signaling pathways. FEBS Journal. (2018) Vol. 285(7):1251-1276.
12. Tiwari R, Sahu I, Soni B, […], Gowda H, and Vaidya M.M*. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation on Keratin-8 in skin squamous cell carcinoma derived cell line. Proteomics. (2017) Vol. 17, Issue 7.
13. Sahu I#, Singh S.K#, Mali S.M, Hemantha H.P, Kleifeld O, Glickman M.H*, and Brik A*. Synthetic uncleavable ubiquitinated proteins dissect proteasome deubiquitination and degradation and highlight distinctive fate of tetraubiquitin. Am. Chem. Soc. (2016) Vol. 138, 16004−16015. [# Equal Contribution].
14. Hjerpe R, Bett J.S, Keuss M.J, Solovyova A, McWilliams T.G, Johnson C, Sahu I, Varghese J, […], Glickman M.H, Trost M, Knebel A, Marchesi F, and Kurz T*. UBQLN2 connects the proteasome with the HSP70 system to promote autophagy-independent protein aggregate clearance. Cell. (2016) Vol. 166 (4), 935-949. See publication
15. Sahu I, Sangith N, Ramteke M, Gadre R, Venkatrama P*. A novel role for the proteasomal chaperone PSMD9 and hnRNPA1 in enhancing IκBα degradation and NF-κB activation – functional relevance of predicted PDZ domain–motif interaction. FEBS Journal. (2014) Vol. 281 (11), 2688-2709. See publication
16. Sangith N, Srinivasaraghavan K, Sahu I, Desai A, […], Venkatraman P*. Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules. FEBS Openbio. (2014) Vol. 4, 571–583. See publication

1. Marie-Curie Individual Fellowship and Grant, H2020-MSCA-IF, European Commission for Post-Doctoral research, and career development. At Prof Michael Glickman’s Lab in the Faculty of Biology at Technion, Israel; from Nov 2017 to Oct 2019. (Grant amount: €182,500.00).
2. Daniel Turnberg Travel Fellowship Award, The Academy of Medical Sciences, Wellcome Trust, UK. The grant is for a 1-month research project in Prof Helen Walden’s Lab at the University of Glasgow, Scotland during the month of Jan-Feb 2020. (Fellowship amount: £3,500.00).
3. FEBS – Short-Term Fellowship Award, Europe. The grant is for a short-term (45 days) research project in Prof Helen Walden’s Lab at the University of Glasgow, Scotland from Jun-Jul 2019. (Fellowship amount: €3,672.00).

4. General Travel Grant – 2022, Biochemical society, UK for presenting data in an International Conference “XI-ZOMES Meeting” – at Magdeburg, during 1-3 September 2022, organized by the University of Magdeburg, Germany
5. FEBS- Young Scientist Forum (YSF) Award – 2020/2021 and International Sponsored Travel grant, Biochemical Society, UK for FEBS-Congress meeting in Slovenia during 1-9 Jul 2021.
6. Early Career Bursaries, Biochemical Society, UK for presenting research data as a Poster presentation in a Meeting in Edinburgh, Scotland organized by Biochemical Society, UK during 17-19 Jun 2019.
7. Marie Curie Alumni association (MCAA) Micro One-World Grant, for attending European Research Day-2018 in Bangalore, India organized by MCAA Indian-Chapter and EURAXESS-India on 26th Sept 2018.
8. FEBS- Young Scientist Forum (YSF) Award for attending FEBS young scientist meeting and presenting a short talk at FEBS Congress during 7-14-Sept 2017.
9. Early Career Bursaries, Biochemical Society, UK for presenting research data as a Poster presentation in a Meeting at Oxford organized by Biochemical Society, UK during 26-28 Jun 2017.
10. Sam Mistry Travel Award, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India for presenting research data at an international conference in Philadelphia, US organized by ASCB during 6-10 Dec 2014.
11. Senior Research Fellowship – SRF (Sept 2012 – July 2015) and Junior Research Fellowship – JRF (Aug 2010 – Aug 2012). At ACTREC-Tata Memorial Cancer Research Centre, Kharghar, Navi Mumbai-410210, India for PhD research.
12. National Eligibility Test (NET) for Junior Research Fellowship and Lectureship – 2009 (AIR 330). Human Resource Development Group, Council of Scientific and Industrial Research (CSIR)/ University Grant Commission (UGC), India.
13. GATE-2010 in Life Science (Score 459, AIR 387). National Coordination Board – GATE, Department of Higher Education, Ministry of Human Resources Development (MHRD), Government of India.
14. Senior Research Fellowship – SRF (2009), National Agricultural Innovation Project (NAIP), Indian Council of Agricultural Research (ICAR), India at CIFA, Bhubaneswar, Odisha.

1. Presenting a Talk (selected) at an International Conference “Deubiquitylases and Ubl-proteases: from fundamental principles to therapeutic opportunities” at Edinburgh, Scotland, UK during 19-21 June 2023, organized by Biochemical Society, UK.
2. Presented a short Talk (selected) at an International Conference “XI-ZOMES Meeting” – in Magdeburg, during 1-3 September 2022, organized by University of Magdeburg, Germany.
3. Presented a talk (on Zoom/selected) at an international meeting “9th Proteasome & Autophagy Congress” in Clermont-Ferrand, France during 13-15 October 2021.
4. Presented short talk (on Zoom/selected) at international meeting “Sci-ROI 2021 virtual Annual Event” during September 25 – October 3, 2021, organized by Sci-ROI@India. (Won the Scientific-Art context).
5. Presented e-Poster and Speed-talk (on Zoom) for an international meeting “20th Young Scientists’ Forum (YSF)” originally planned for Lovran, Croatia, June 15th to June 18th, 2021, organized by FEBS, Europe.
6. Presented a Talk (on Zoom/selected) at an International Conference “45th FEBS Congress” – originally planned for Ljubljana, Slovenia, during July 3rd to July 8th, 2021, organized by FEBS, Europe.
7. Presented Poster and short talk at an international meeting “YIM-2020” at Mahablipuram, India, on 14-18 February 2020 organized by IndiaBioscience and DBT-India.
8. Presented Poster at an International Conference “Deubiquitylases: from mechanism to physiology”, in Edinburgh, Scotland, 17-19 June 2019 organized by Biochemical Society, UK. (Best Poster Award).
9. Presented a Digital Poster at “6th MCAA General Assembly & Conference” in Vienna, Austria, during 24-25 February 2019 organized by MCAA.
10. Presented a Talk (selected) at an International Conference “X-ZOMES Meeting” – in Akko, Israel, during 4-7 February 2019, organized by Technion, Haifa, Israel.
11. Presented a Poster at an International Conference “The Proteasome Hub” – in Munich, Germany during 12-14 February 2018, organized by PROTEOSTASIS, Europe.
12. Presented a Talk (selected) at an International Conference “42nd FEBS Congress” – in Jerusalem, Israel, during 10-14 September 2017, organized by FEBS, Europe.
13. Presented Poster at an International meeting “17th Young Scientists’ Forum (YSF)” in Jerusalem, Israel, 7-10 September 2017 organized by FEBS, Europe.
14. Presented Poster at an International meeting “Deubiquitylases: from structure to physiology”, in Oxford, UK, 26-28 June 2017 organized by Biochemical Society, UK.
15. Presented a Short-Talk & Poster at an International Meeting/Workshop “3rd PROTEOSTASIS Action Meeting” – in Lisbon, Portugal during 2-5 Nov 2016, organized by COST Action BM1307 Proteostasis, EU. (Best Poster Award).
16. Presented Talk at an International Meeting organized by “Ubiquitin-Proteasome System-Israel Club (UPSIC)” at Weizmann Institute of Science, Israel, held on 29th September 2016.
17. Presented Poster at an International Conference “Carcinogenesis-2015”, organized by Carcinogenesis Foundation, USA and ACTREC-TMC, India on 11-13 February 2015 at Advanced Centre for Treatment Research and Education in Cancer, Navi Mumbai, India.
18. Presented Poster at an International Conference “American Society of Cell Biology (ASCB)/ International Federation for Cell Biology (IFCB) Meeting-2014” held on 06-10 December 2014 in Philadelphia, PA, USA.
19. Presented Poster at an International Conference “The XXXVII All India Cell Biology Conference on Cell Dynamics and Cell Fate (AICBC-2013)”, conducted by Indian Society for Cell Biology on 22-24 December 2013 at Indian Institute of Science, Bangalore, India.
20. Presented Poster at an International Conference “32nd Annual Convention of Indian Association for Cancer Research (IACR-2013)” on 13-16 February 2013 at Delhi University, New Delhi, India. (Best Poster Award).

Academic Experience:

• ASSISTANT PROFFESOR │ April 2023 to Present│ Department of Medical Research, Faculty of Medicine & Health Sciences, SRM-IST Chennai, India
• POST-DOCTORAL RESEARCHER │ Feb 2022 to March 2023 │ Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
• POST-DOCTORAL RESEARCHER │ March 2021 to Feb 2022 │ Department of Cell Biology, Harvard Medical School, Boston, USA
• EUROPEAN SENIOR RESEARCHER │ Nov 2019 to Feb 2021│ Faculty of Biology, Technion – Israel Institute of Technology, Haifa, Israel
• MARIE-CURIE POST-DOCTORAL FELLOW (MSCA-IF) │ Nov 2017 to Oct 2019 │ Faculty of Biology, Technion – Israel Institute of Technology, Haifa, Israel
• VISITING RESEARCH FELLOW │ June 2020 to July 2020 & Jan 2021 to Feb 2021 │ School of Molecular Biosciences, University of Glasgow, Scotland, UK
• POST-DOCTORAL FELLOW │ Nov 2015 to Oct 2017 │ Faculty of Biology, Technion – Israel Institute of Technology, Haifa, Israel

• 2022: Topical advisory panel member (Proteomics section) for the journal “MDPI – Biology”.
• 2017: Marie-Curie Alumni Association (MCAA), Europe. MCAA-India Chapter.
• 2017: Biochemical Society, UK
• 2016: Israel Society for Biochemistry and Molecular Biology (ISBMB), Israel

1. Research dissemination advisory activity for PG, PhD and Faculty members at the department of Medical Microbiology, Faculty of Medicine & Health Sciences, SRM-IST, Chennai, India.
2. Co-Supervisor of thesis research work:

• Shahar Levi, PhD thesis (2021 – present), Faculty of Biology, Technion-Israel Institute of Technology, Israel. (Supervisor: Prof. Michael Glickman)
• Roni Morag, Master Thesis (2019 – 2021) at Faculty of Biology, Technion-Israel Institute of Technology, Israel. (Supervisor: Prof. Michael Glickman)

3. Working as a Reviewer for the journals BBA-Gene Regulatory Mechanism, and MDPI – Biomolecules.
4. Working as an Evaluator of Marie-Curie (MSCA-PF, Horizon-2020, EU) Life sciences postdoc proposals from the year 2020 to present.
5. Teaching Associate (July 2008 – Feb 2009) at the Department of Microbiology, Orissa University of Agriculture and Technology (OUAT), Bhubaneswar, Odisha. Course taught: Basic Microbiology and molecular biology techniques. Level: Master students.