Research Projects
2024-2025
| S. No. | PI | Title | Duration | Funding Agency |
| 1 | Dr. R. Pachaiappan | Conference funding (Conference on Structural Biology and Drug Discovery (CSBDD)” held from October 08 to 10, 2024 organized by the Department of Biotechnology, School of Bioengineering) | October 08 to 10, 2024 | DBT |
| 2 |
Dr. K. M. Ram Kumar |
Targeting Inflammasome Activation by Natural Compounds to Attenuate Endothelial Dysfunction in Type 2 Diabetes (IIRPSG-2024-01-02666) | Approved | ICMR |
| 3 | Study on the Role of SLIT2-ROBO1 Signaling and Epigenetic Regulation in Diabetic Foot Ulcer Progression and Wound Healing (IIRPSG-2024-01-03147) | Approved | ICMR | |
| Unraveling the therapeutic potential of the endogeneous derived copper binding peptides on retinal vascular endothelial dysfunction in experimental diabetic retenopathy | Approved | DBT |
2023-2024
| S. No. | PI | Title | Duration | Funding Agency |
| 1 | Dr. K. Ramani | A strategic approach on biofilm-mediated enzymatic degradation of microplastics and plastic derived compounds in activated sludge generated from sewage treatment plant and toxicity assessment | 2023-24 | Tamil Nadu State Council for Science and Technology, Government of Tamil Nadu |
2022-2023
| S. No. | PI | Title | Duration | Funding Agency |
| 1 | Dr. S. Sahabudeen | Study on epigenetic effects of BPA using experimental models: mice and Drosophila | 2022-24 | SPARC |
| 2 | Dr.K.M. Ramkumar | Study on epigenetic modulation of Nrf2 by small Molecules for diabetic foot ulcer | 2022-25 | ICMR |
| 3 | Dr.K.Ramani | An integrated Technology for the treatment of microplastics and plastic derived compounds from municipal landfill leachate | 2022-25 | DST-SYST |
| 4 | Dr. Sarada, D V L | Study on the effect of oleo gum resin of Commiphora wightii and its active principles on lipoprotein lipase and lipid droplet mobility during adipogenesis | 2022-25 | ICMR |
| 5 | Dr.K.M. Ramkumar | Plant based ferroptosis inhibitors: A novel approach for the management of Diabetes | 2022-25 | ICMR |
| 6 | Dr. V. Vinoth Kumar | Biomanufacturing platform for biostimulants and anti-microbial compounds: From designing principles to lab-scale production | 2022-24 | Prism Crop Science Private Limited |
| 7 | Dr.K.M. Ramkumar | Development of a Biosensor Integrated Three-Dimensional Wound Model with Optimal Mechanical Properties for Studying Wound Healing Applications | 3 months | SERB |
| 8 | Dr.K.Ramani | Validation of Technologies for the treatment of wastewater using bench scale prototypes | 2022-25 | Auga Treat Private Limited |
| 9 | N. Selvamurugan (Akshaya R L.) | Regulation of ATF-3 by miRNAs in Human Breast cancer cells | 5 Years | DST-INSPIRE |
| 10 | Dr. N. Selvamurugan (Saranya I) | Regulation of bone remodeling by miRNAs | 5 Years | DST-INSPIRE |
| 11 | Dr.K.Ramani (Swathi KV) | An integrated biotechnological approach for the treatment of hydrocarbon containing petroleum oil refinery wastes | 5 Years | DST-INSPIRE |
| 12 | Dr.K.Ramani (Maseed Uddin) | Treatment of microplascs and refractory organics in sanitary landfill leachate using an integrated biotechnological approach | 5 Years | DST-INSPIRE |
| 13 | S. Sahabudeen (Swetha) | A study on the fabrication of chitosan/alginate coated probiotic beads and analyse its role in modulating acrylamide induced toxicity using Drosophila melanogaster as in vivo model. | 5 Years | DST-INSPIRE |
| 14 | Dr.G.Dhanavathy | Molecular docking, invitro screening of small molecules for inhibition of KDM3A in cancer cells | 1 year | BogaR Laboratories |
| 15 | Dr.S.Rupachandra | Development of Bioactive Cyclic peptide-based Hydrogels for biomedical applications | 1 year | Dextrose Technologies Pvt Ltd. |
Sponsored Research Project (National)
| PI | Title | Duration | Funding Agency |
| Dr. R. Pachaiappan | Conference funding (Conference on Structural Biology and Drug Discovery (CSBDD)” held from October 08 to 10, 2024 organized by the Department of Biotechnology, School of Bioengineering) | 2024 | DBT |
| Dr. K. M. Ram Kumar | Targeting Inflammasome Activation by Natural Compounds to Attenuate Endothelial Dysfunction in Type 2 Diabetes | 2025-2028 | ICMR |
| Dr. K. M. Ram Kumar | Study on the Role of SLIT2-ROBO1 Signaling and Epigenetic Regulation in Diabetic Foot Ulcer Progression and Wound Healing | 2025-2028 | ICMR |
| Dr. K. M. Ram Kumar | Anti-diabetic and Immuno-modulatory Effect of Unani Formulation ‘Safūf-i-Dhayābītus” | 2024-2027 | Ministry of AYUSH |
| Dr. K. M. Ram Kumar | Unraveling the therapeutic potential of the endogeneous derived copper binding peptides on retinal vascular endothelial dysfunction in experimental diabetic retinopathy | 2024-2027 | DBT |
| Dr. K. M. Ram Kumar | Anti-osteoarthritic effects of Global CBD formulation in a rat model of monosodium iodoacetate-induced Osteoarthritis | 2024-2025 | Unique Therapeutics Global, Czech Republic |
| Dr. K. M. Ram Kumar | Screening and Identification of Novel Acetylcholinesterase Inhibitors from Synthetic Compounds Using Bioassay | 2025-2026 | VasiPharm LLC, USA |
| Dr. K. M. Ram Kumar | Exploring the Molecular Mechanisms of Bisphenol A-Induced Endothelial Dysfunction in Cardiovascular Diseases: Implications for Ferroptosis in Environmental Health. | 2024-28 | DST-INSPIRE (Ms. Yukta) |
| Dr.K.Ramani | Technology Know How and Guidance for designing and constructing Sewage Treatment Plant | 2025-2028 | Pristine Enviro Technologies Ltd |
| N. Selvamurugan | Identification and Functional Characterization of TGF-β1-mediated Activating Transcription Factor 3 sumoylation in Breast cancer Bone Metastasis | 2024-2027 | SERB-CRG |
| Dr. V. Vinoth Kumar | Multi-product integrated biorefinery of soymeal: from functional peptides and amino acids to high-value specialties | 2024 – 2025 | Prism Crop Science Private Limited |
| Dr. S. Sahabudeen | Pilot study on AMR in water bodies. | 2024 – 2025 | EBP Inc., Japan |
| Dr. S. Sahabudeen | The study planning about the microplastics in water-based samples | 2024 – 2025 | EBP Inc., Japan |
| Dr. S. Sahabudeen | Detection of virus in water based samples | 2024 – 2025 | EBP Inc., Japan |
| Dr. Koustav Sarkar | CCCTC-binding factor (CTCF) mediated epigenetic regulation of T helper (TH) cell differentiation linked to Non-Small Cell Lung Cancer (NSCLC) modulated through N6-methyladenosine (m6A) RNA methylation | 2024 – 2027 | ICMR |
| Dr. Koustav Sarkar | Centre for Advanced Research (CAR) to promote Translational Studies of Regionally Relevant Unmet needs in Hematological Malignancies with emphasis on High-risk and Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) | 2024 – 2029 | ICMR |
| Dr. Koustav Sarkar | Evaluation of epigenetic aging and its modulation by β-Nicotinamide mononucleotide (β-NMN) in patients diagnosed with coronary artery disease | 2024 – 2027 | ICMR |
| Dr. Satish Kumar Rajasekharan | Development of real time PCR based high throughput system for the detection of biofilm forming Escherichia coli medical devices | 2025-2027 | SERI (SRMIST) |
| Dr. Satish Kumar Rajasekharan | Postbiotics derived from nomadic Lactobacilli for treatment of polybiofilm infections in diabetic foot ulcers | 2025-2028 | ANRF (PM ECRG) |
| Dr. Balamurugan Srinivasan | System and molecular biology strategies to empower sustainable bioenergy resources | 2020-2025 | DBT-Ramalingaswami Fellowship |
| Dr. Nitya Nandkishore | Organoid model to investigate the effects of gestational diabetes on early heart development | 2025-2028 | ANRF (PM ECRG) |
| Dr. Sarada, DVL (Ms. D. Sumana Pratyusha) | Developmental and Stress Responses – Role of RALF | 2024-2027 | CSIR – SRF |
| Dr.S.Rupachandra | Identification, Characterization and evaluation of Potential biological properties of bioactive compounds from Marine Seaweeds. | 2025-2026 | Sea2Farms Crop Nutrition Pvt.Ltd, |
| Dr. M. Vairamani | A rapid non-invasive urinary test for the detection of obstructive Uropathy | 2015-2017 | Department of Biotechnology (DBT) |
| SRM – DBT Platform for Research and Skill Development in Advanced Life Science Technologies | 2015-2020 | Department of Biotechnology (DBT) | |
| Dr. R.A. Nazeer | Radical scavenging activity of antioxidant peptides from mantles of three marine cephalopods | 2012-2015 | DBT |
| Angiotensin converting enzyme inhibitory (ACEI) peptides from two Squilla species | 2014–2017 | DST-SERB | |
| Dr. N. Selvamurugan | Regulation of mesenchymal stem cell towards osteogenic cell lineage by micro RNAs | 2011-2014 | Indian Council of Medical Research (ICMR) |
| Activating transcription factor-3: a potential target gene for breast cancer progression in vivo | 2011-2014 | ICMR | |
| A novel hydrogel containing zinc doped chitosan/nano-hydrozyapatite/beta-glycerophosphate for bone tissue engineering | 2013-2016 | Council of Scientific and Industrial Research (CSIR) | |
| In vitro and in vivo biocompatibility of chitosan/gelatin/ graphene oxide scaffolds for bone tissue engineering | 2014-2017 | CSIR | |
| Regulation of Rnux2, a bone transcription factor by transforming growth factor-beta1 for metalloproteinase 13 expression in osteoblastic cells | 2014-2017 | DST-SERB | |
| A molecular study of activating transcription factor-3 and its interacting proteins in human breast cancer cells | 2016-2019 | DBT | |
| Regulation of parathyroid hormone stimulation of matrix metalloproteinase-13 expression in osteoblastic cells by microRNAs | 2017-2020 | DBT | |
| Identification of microRNAs regulating TGF-beta1-stimulated ATF3 expression in human breast cancer cells | 2019-2022 | ICMR | |
| Transforming growth factor-?1 activates Runx2, a bone transcription factor for matrix metalloproteinase-13 expression in osteoblastic cells | 2019-2022 | DST-SERB | |
| Identification of microRNAs regulating Runx2 activity for TGF-beta 1-stimulation of matrix metalloproteinase-13 expression in osteoblastic cells | 2021-2024 | ICMR | |
| Identification and Functional Characterization of TGF-β1-mediated Activating Transcription Factor-3 sumoylation in Breast cancer Bone Metastasis | 2024-2027 | DST-SERB | |
| Dr. K. Ramkumar | Therapeutic potential of Nrf2 activators on Enoplasmic reticulum-induced endothelial dysfunction in diabetes | 2017-2020 | DST-SERB |
| Study on the epigenetic modulation of Nrf2 by small molecules for diabetic foot ulcer | 2021-2024 | ICMR | |
| Study on the effect of Gymnema montanum on endothelial dysfunction in experimental diabetes | 2015-2018 | ICMR | |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) activators on the survival of pancreatic islet grafts in type 1 diabetic mice | 2014-2017 | DBT | |
| Development of a Biosensor Integrated Three-Dimensional Wound Model with Optimal Mechanical Properties for Studying Wound Healing Applications | 2022-2023 | DST-SERB, Govt. of India | |
| Plant based ferroptosis inhibitors: A novel approach for the management of diabetes | 2023-24 | ICMR | |
| Dose range finding and acute toxicity profile of Caplin formulation in mice | 2021 | Caplin Steriles Limited, Chennai | |
| Identification of Bacterial Tracking on mouse skin wound models using ILLUMINATE | 2021 | ADIUVO Diagnostics Pvt. Ltd, Nellore | |
| A cell-based system for high throughput screening of Nrf2 activators and its role in protecting pancreatic ?-cell apoptosis | 2013-2016 | DST-SERB | |
| Dr. Lilly M Saleena | In vitro validation of MMP8 and MMP13 inhibitors – A step towards drug discovery for osteoarthritis | 2017-2020 | ICMR |
| Dr. K. Ramani | A mariner transposon based mutagenesis system for enhanced production of biosurfactants to be applied for oil removal from petroleum oil refinery sludge | 2017–2020 | DBT |
| Upgradation (performance improvement) of existing biological system located at ETP of Heubach Colour Pvt. Ltd., Gujarat. | 2013-2016 | Heubach Colour Pvt. Ltd., Gujarat, India. | |
| Bioremediation of bottom tank oil sludge from petroleum oil refinery using biosurfactants. | 2016-2017 | Chennai Petroleum Corporation Ltd. India | |
| An integrated technology for treatment of microplastics and plastic derived compounds from municipal landfill leachate | 2020–2023 | DST-SERB | |
| Orchid Drug Products Testing | 2020 | Orchid Healthcare, Orchid Pharma Chennai | |
| Dr. S. Sahabudeen | SPARC (Scheme for Promotion of Academic and Research), Govt. of India | 2023-2025 | SPARC, Ministry of Education |
| Investigation of synergic effects of methylene blue adsorbed cerium oxide nanoparticles as therapeutics for alzheimer’s disease | 2016-2019 | DST-SERB | |
| Dr. V. Vinoth Kumar | Sludge derived surface active compounds assisted mycoremediation of costal zones contaminated with hydrophobic organic compounds | 2020-2023 | All India Council for Technical Education |
| Biomanufacturing platform for biostimulants and anti-microbial compounds: From designing principles to lab-scale production | 2022-24 | Prism Crop Science Private Limited | |
| Genetically modified Trichoderma atroviride: A robust biotechnological tool for the production of second generation lignocellulosic biofuels and subsequent wastewater treatment | 2017-2020 | DST-SERB | |
| Dr. Koustav Sarkar | Wiskott aldrich syndrome protein (WASp) mediated epigenetic regulation of T helper (Th) cell differentiation linked to malignancies through R-loop modulation | 2017-2020 | DST-SERB |
| CCCTC-binding factor (CTCF) mediated epigenetic regulation of T helper (TH) cell differentiation linked to Non-Small Cell Lung Cancer (NSCLC) modulated through N6-methyladenosine (m6A) RNA methylation | 2024-2027 | ICMR | |
| Evaluation of Epigenetic Aging and its Modulation by Beta-Nicotinamide Mononucleotide (Beta-NMN) in Patients Diagnosed with Coronary Artery Disease (C0-PI) | 2024-2027 | ICMR | |
| Centre for Advanced Research to Promote Translational Research for Regionally Relevant Unmet Oncologic Need in Hematological Malignancies and Blood & Marrow Transplant (BMT) (Co-PI) | 2024-2029 | ICMR | |
| Dr.D.V.L.Sarada | Study on the effect of Oleo-Gum resin of Commiphora wightii and its active principles on lipoprotein lipase and lipid droplet motility during adipogenesis | 2021-24 | ICMR |
| Dr. P. Kanagaraj | Targeting epigenetic regulation for inhibiting pancreatic cancer stem cells | 2018-2021 | DST-SERB |
| Dr. W. Richard Thilagaraj | Enzyme mediated bioremediation of radionuclides and heavy metals from effluents employing engineered alkaline phosphatase(s) | 2018-2021 | DST-TARE |
| Dr. K. Ramkumar | Therapeutic potential of Nrf2 activators on Enoplasmic reticulum-induced endothelial dysfunction in diabetes | 2017-2020 | DST-SERB |
| Study on the epigenetic modulation of Nrf2 by small molecules for diabetic foot ulcer | 2021-2024 | ICMR | |
| Study on the effect of Gymnema montanum on endothelial dysfunction in experimental diabetes | 2015-2018 | ICMR | |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) activators on the survival of pancreatic islet grafts in type 1 diabetic mice | 2014-2017 | DBT | |
| Development of a Biosensor Integrated Three-Dimensional Wound Model with Optimal Mechanical Properties for Studying Wound Healing Applications | 2022-2023 | DST-SERB, Govt. of India | |
| Plant based ferroptosis inhibitors: A novel approach for the management of diabetes | 2023-24 | ICMR | |
| Dose range finding and acute toxicity profile of Caplin formulation in mice | 2021 | Caplin Steriles Limited, Chennai | |
| Identification of Bacterial Tracking on mouse skin wound models using ILLUMINATE | 2021 | ADIUVO Diagnostics Pvt. Ltd, Nellore | |
| A cell-based system for high throughput screening of Nrf2 activators and its role in protecting pancreatic ?-cell apoptosis | 2013-2016 | DST-SERB | |
| Dr. M. Pandimadevi | Evaluation of vetiver for uptake and immobilization of uranium and residual radionuclides in mill talling soil and post treated effluents | 2008-2011 | Board of Research in Nuclear Sciences (BRNS), BARC |
| Dr. S. Winkins Santhosh | Screening of environmental estrogen (EE2) using zebra fish brain aromatase gene (CYP19A1B) as a biomarker (RGYI) | 2013–2014 | DBT |
| Dr. S. ThyagaRajan | Health benefits of dietary intake of virgin coconut oil on neural-immune network | 2014-2017 | Coconut Development Board |
| Modulation of neural – immune signaling by estrogen in reproductive aging | 2008-2012 | DST-SERB | |
| Neuroendocrine-immune Interactions in mammary tumorigenesis | 2009-2013 | DBT | |
| Dr. E. Berla Thangam | Targeting histamine H4 receptor for the development of new antihistamines | 2012-2015 | DBT |
| Effect of new selective H4R antagonist N-(2-aminoethyl)-5chloro-1H-indol-2-carboxamides in a mouse model of allergic asthma | 2018–2019 | DST-SERB | |
| Molecular mechanism of neonatal sepsis. | 2011-2014 | DBT | |
| Dr. Waheeta Hopper | Development of drug lead molecules against microorganisms used as bioweapons | 2012-2015 | Defence Research and Development Organisation |
| Identification of efflux protein inhibitors to Gram-negative organisms using bioinformatics tools and in vitro analysis and Crystallographic studies of target membrane protein-inhibitor complexes | 2009-2014 | DBT |
Sponsored Research Project (International)
| Sl. No | Name of the Faculty | Title of the project | Country of colloboration | Funding agency |
| 1 | Dr. S. Sahabudeen | Study on epigenetic effects of BPA using experimental models: mice and Drosophila | Japan | Scheme for Promotion of Academic and Research (SPARC), Government of India |
| 2 | Dr. Koustav Sarkar | Utility of miRNA biomarkers In patients with Acute Myocardial Infarction- A Prospective Pilot Study | Switzerland | Zurich University of Applied Sciences, Switzerland, University of Geneva, Switzerland |
| 3 | Dr. K. M. Ramkumar | Development of a Biosensor Integrated Three-Dimensional Wound Model with Optimal Mechanical Properties for Studying Wound Healing Applications | USA | Department of Science and Technology, DST-SERB, Government of India |
| 4 | Dr. V. Vinoth Kumar | TIGC Catalyst Project | Australia | LaTrobe University, Australia |
| 5 | Dr. V. Vinoth Kumar | Genetically tailored Trichoderma atroviride (Talacc3): A robust biotechnological tool for the production of second-generation lignocellulosic biofuels and subsequent wastewater treatment | Mexico | Department of Science and Technology , Government of India |
| 6 | Dr. M. Vairamani | A rapid non-invasive urinary test for the detection of obstructive Uropathy | USA | Department of Biotechnology, Government of India |
| 7 | Dr. Waheeta Hopper | Identification of efflux protein inhibitors to gram negative organisms using bioinformatics tools and in vitro analysis and Crystallographic studies of target membrane protein-inhibitor complexes | Japan | Department of Biotechnology, Government of India |
Infrastructure Support (DST/DBT)
| S. No. | Principal Investigator | Scheme | Duration | Funding agency |
| 1 | Dr. M. Vairamani | DST-FIST to the Department of Biotechnology, School of Bioengineering, SRM IST | 2008-2013 | Department of Science and Technology (DST) |
| DST-FIST to the Department of Biotechnology, School of Bioengineering, SRM IST | 2018-2023 | DST | ||
| SRM-DBT Partnership Platform for Contemporary Research Services and Skill Development in Advanced Life Science Technologies | 2015-2020 | Department of Biotechnology (DBT) |
Student Research Fellowship
| S. No. | Principal Investigator/Student | Title | Duration | Funding Agency/Scheme |
| 1 | Dr. N. Selvamurugan / Ms. Lavanya | Fabrication of Thymol-loaded Sodium alginate/Poly(2-ethyl-oxazoline)/Chitosan based Semi-interpenetrating Hydrogels for Bone Tissue Engineering | 2018 -2023 | DST-Inspire |
| 2 | Dr. S.Sahabudeen / Ms.S. Swetha | A study on the fabrication of chitosan/alginate coated probiotic beads and analyse its role in modulating acrylamide induced toxicity using Drosophila melanogaster as in vivo model | 2022-2027 | DST-Inspire |
| 3 | Dr. K. Ramani / Mr. Maseed Uddin | Treatment of refractory organics in sanitary landfill leachate using an integrated biotechnological approach | 2021 -2025 | DST-Inspire |
| 4 | Dr. Nageswaran / Ms. Shruthi | Elucidating the role of TGF-? signaling during doxorubicin induced chemoresistance in colon cancer cells | 2018 -2023 | DST-Inspire |
| 5 | Dr. N. Selvamurugan / Ms. Akshaya | Regulation of Activating Transcription Factor-3 by MicroRNAs in Human Breast Cancer Cells | 2019-2024 | DST-Inspire |
| 6 | Dr. K. Ramani / Ms. Swathi | An integrated Biotechnological Approach for the Treatment of Hydrocarbon containing Petroleum oil refinery wastes | 2019 -2024 | DST-Inspire |
| 7 | Dr. N. Selvamurugan / Ms. Rohini | A molecular study of Activating Transcription factor 3 and its Interacting proteins in Breast Cancer cells | 2017 -2022 | Department of Biotechnology (DBT-BET) |
| 8 | Dr. Waheeta Hopper / Ms. Ahameethunisa | Cloning and Functional Expression of Amorpha-4, 11-Diene Synthase, A key enzyme in Artemisinin biosynthesis, from Artemisia annua in to Cichorium intybus | 2012-2014 | CSIR – RA |
| 9 | Dr. R.A.Nazeer/Akshad Balde | Transdermal delivery of marine animal derived venom therapeutics to target inflammatory arthritis | 2023-2028 | DST-Inspire |
| 10 | Dr. N. Selvamurugan/I. Saranya | Regulation of TGF-beta1-stimulation of Runx2 activity for matrix metalloproteinase-13 expression by microRNAs in osteoblastic cells | 2022-2027 | DST-Inspire |
| 11 | Dr. D.V.L. Sarada/G. Vasantha | Enhancement of Carotenoid Production in selected microalgae using UV-B radiation. | 2023-2028 | DST-Inspire |
