Menu
Cancer Immunology and Gene Editing Technology Lab
Cancer Immunology and Gene Editing Technology Lab
Cancer immunotherapy has emerged as a promising strategy for the treatment of a broad spectrum of malignancies, ranging from haematological to solid tumours.
Cancer immunology is an interdisciplinary branch of biology that is concerned with understanding the role of the immune system in the progression and development of cancer. The most well-known application is cancer immunotherapy, which uses the immune system as a treatment for cancer. Cancer immunosurveillance and immunoediting are based on protection against the development of tumours in animal systems and the identification of targets for immune recognition of human cancer. Gene editing is a type of genetic engineering in which DNA is inserted, deleted, modified, or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserted genetic material into a host genome, genome editing targets the insertions at site-specific locations.
Specifications
Current Equipments
Utilization
Profile
One of the principal approaches to cancer immunotherapy is the transfer of naturally occurring or engineered tumor-specific T-cells into patients, a process called “Adoptive Cell Transfer”, (ACT). Allogeneic T-cell development is dependent on the use of a gene-editing tool to modify donor-extracted T-cells and prepare them to specifically act against tumour cells with enhanced function and durability and the fewest side effects. In this context, CRISPR technology can be used to produce universal T-cells equipped with recombinant T- cell receptors (TCR) or chimeric antigen receptors (CAR) through multiplex genome engineering using Cas nucleases. The robust potential of CRISPR-Cas in preparing the building blocks of ACT immunotherapy has broadened the application of such therapies, and some of them have gotten FDA approval. In this lab, we are mainly working in the field of immuno-oncology associated with CRISPR/Cas9 technology.
Contact Persons
Dr. Koustav Sarkar
Research Assistant Professor
koustavm@srmist.edu.in
Ms. Sudeshna Rakshit
Research Scholar
sudeshns@srmist.edu.in
Ms. Geetha S.
Research Scholar
gs6491@srmist.edu.in
No data was found
Block Name: Sir C.V. Raman Research Park Room no: 210 Open Door Access Time: 9 AM to 5 PM
